People

Principal Investigator

Manju M. Hingorani

Manju received her B.S. in Pharmaceutical Sciences from K.M.K. College, University of Bombay, India in 1990.  She completed her Ph.D. in 1996 in Biochemistry at The Ohio State University.  She investigated the bacteriophage T7 helicase mechanism, mentored by Dr. Smita S. Patel.  She then moved to The Rockefeller University as a postdoctoral fellow to study E. coli clamp and clamp loader proteins that are essential for DNA replication, and was mentored by Dr. Mike O’Donnell.  In 2000, she became an Assistant Professor of Molecular Biology and Biochemistry at Wesleyan University, where she is currently an Associate Professor.  Her research is focused on the workings of DNA replication and DNA mismatch repair proteins from S. cerevisiae and T. aquaticus model organisms.

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Postdoctoral Researchers

Miho Sakato

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Graduate Students

Yayan Zhou

Anushi Sharma

Anushi received her B.Sc. in Microbiology and Pharmaceutical Chemistry at Maharaja Ranjit Singh College, Indore, India, in 2002.  She completed her M.Sc. in Industrial Microbiology from the School of Life Sciences, Devi Ahilya University, Indore, India, in 2004.  From 2004 – 2008, she worked on bacterial bioremediation of toxic organic compounds at the Indian Institute of Technology, Kanpur, India.  Currently she is a PhD student at Wesleyan University working with fluorophore-labeled DNA mismatch repair proteins to understand their mechanism of action.

Shreya Sawant

Shreya received her B.Sc in Chemistry, Zoology and Microbiology from Mount Carmel College, Bangalore, India in 2009. Upon graduation she took up a position as a research assistant at the Yale School of Medicine at Prof. William Konigsberg’s laboratory. There she studied the effect of Cadmium on RB69 DNA polymerase. She joined the Molecular Biology and  Biochemistry department at Wesleyan University in 2010. She is currently working on the kinetic mechanisms of DNA mismatch repair proteins


Undergraduate Students

Xiaoyu Yu

Xiaoyu graduated from Stuyvesant High School in 2009. She is currently a junior in Wesleyan University majoring in Molecular Biology and Biochemistry. Xiaoyu hopes to better understand the mechanism of how Msh2-Msh3 processes insertion/deletion loops in DNA, leading to their repair or to repeat expansions that are implicated in many diseases. After graduating from Wesleyan, she hopes to pursue a career in the biomedicinal field.